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The rise in extreme acute toxicity next SC use could possibly be attributed on the overstimulation of CB1 receptors by strong analogues, specially fluorinated SCs like AM-2201. On top of that, the acute medical presentation observed in circumstances of SC toxicity might be because of serotonin syndrome, indicating unintended off-target activity.

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The dearth of regulation and high quality Regulate in the creation of these substances further enhances the hazards related to their use.

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